Palbociclib is also a weak time-dependent inhibitor of cyp3a and indinavir is a sensitive cyp3a4 substrate.
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progesterone moderate indinavir decreases the metabolism of oral contraceptives and non-oral combination contraceptives; the auc for ethinyl estradiol and norethindrone increased by 24 -17 and 26 -14 , respectively, when coadministered with indinavir.
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