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patients taking other drugs that are substrates of cyp450 3a4, especially patients with renal and or hepatic impairment, may require dosage adjustment when starting or stopping concomitantly administered diltiazem in order to maintain optimum therapeutic blood levels.

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lurasidone major diltiazem is a moderate inhibitor of cyp3a4 and has the potential for interactions with substrates of cyp3a4 such as lurasidone.
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Computer-based simulations showed that at a daily dose of 480 mg of diltiazem, an 8- to 9-fold mean increase in simvastatin auc can be expected.

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